Synthesis of Nucleosides and Related Compounds. XXXI. Resolution of 9-[c-4,t-5-Bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(±)-BCA] by Means of High-Pressure-Mediated Deamination with Adenosine Deaminase

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概要

• 論文の詳細を見る

• Deamination of an anti-human immunodeficiency virus (anti-HIV) carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine (BCA) by adenosine deaminase under a variety of pressures (1 bar-6 kbar) was investigated. It was found that, while (+)-BCA was practically unaffected, the deamination of (-)-BCA was remarkably enhanced under 4 kbar to give the corresponding (-)-hypoxanthine derivative [(-)-BCH] in nearly 100% ee.

• 公益社団法人日本薬学会の論文
• 1993-06-15

著者

• 金子 主税

  東北大学

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 佐藤 弘

  Pharmaceutical Institute Tohoku University

• 豊田 朱見

  Pharmaceutical Institute, Tohoku University

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

• 白石 拓也

  Pharmaceutical Institute, Tohoku University

• 相川 豊夫

  Department of Biology, College of General Education, Niigata University

• 豊田 朱見

  東北大学薬学部薬化学教室

• 白石 拓也

  Pharmaceutical Institute Tohoku University

• Katagiri N

  Pharmaceutical Institute Tohoku University

• 相川 豊夫

  Department Of Biology College Of General Education Niigata University

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