Studies on Ketene and Its Derivatives. XXXIX. Reaction of Diketene with Semicarbazone
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概要
- 論文の詳細を見る
Reaction of aromatic ketone semicarbazone, such as propiophenone semicarbazone (VIIa), acetophenone semicarbazone (VIIb) and benzophenone semicarbazone (VIIc), with diketene in glacial acetic acid gave the N-alkylidene aminouracil derivatives (VIIIa-c) in good yield. Hydrolysis of VIIIa-c with 10% hydrochloric acid afforded 1-amino-6-methyluracil (IX). Similarly, benzaldehyde semicarbazone (VIId) reacted with diketene to give 1-benzalamino-6-methyluracil (VIIId), which, on catalytic reduction, was reduced to 1-benzylamino-6-methyluracil (XIV). Reaction of aliphatic ketone semicarbazone, such as acetone semicarbazone (VIIe), methylethylketone semicarbazone (VIIf), and cyclohexanone semicarbazone (VIIg), did not afford the VIII-type compounds, but gave IX.
- 公益社団法人日本薬学会の論文
- 1970-11-25
著者
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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片桐 信弥
Health Sci. Univ. Hokkaido Hokkaido Jpn
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片桐 信弥
Pharmaceutical Institute Tohoku University
-
加藤 鉄三
Pharmaceutical Institute. Tohoku University
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