Studies on Ketene and Its Derivatives. LXII. Reaction of Ketene and Diketene with 2-Pyridyl Isocyanate and Isothiocyanate
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2-Pyridylisocyanate (IIa) reacted with diketene to give 3-acetyl-2-hydroxy-4H-pyrido [1,2-α] pyrimidin-4-one (IIIa), 3-acetyl-4-hydroxy-6-methyl-1-(2-pyridyl)-2-pyridone (IVa), and 2-methyl-4H-pyrido [1,2-α] pyrimidin-4-one (Va). On the other hand, reaction of diketene with 2-pyridylisothiocyanate (IIb) afforded only 3-acetyl-2-mercapto-4H-pyrido-[1,2-α] pyrimidin-4-one (IIIb). Reaction of ketene with IIa and IIb gave rise to 2-acetoxy-4H-pyrido [1,2-α] pyrimidin-4-one (VIa) and 2-acetylthio-4H-pyrido [1,2-α] pyrimidin-4-one (VIb), respectively.
- 公益社団法人日本薬学会の論文
- 1974-07-25
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