Isoxazole Derivatives as Centrally Acting Muscle Relaxants. I. : Synthesis and Activity of 5-(3-Aminopropyl)amino-3-phenylisoxazole Derivatives
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概要
- 論文の詳細を見る
A series of 5-amino-3-phenylisoxazole derivatives was synthesized and evaluated as part of a search for new types of centrally acting muscle relaxants. The derivtives with an alkylaminopropyl moiety exhibited muscle relaxant activity comparable to that of tolperisone (1), but this activity was accompanied by strong general central nervous system (CNS) depressant and slight anticonvulsant activities.On the other hand, the derivative with a propanamide moiety exhibited a favorable pharmacological profile for a selective muscle relaxant with little CNS depressant action.
- 社団法人日本薬学会の論文
- 1986-04-25
著者
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水柿 道直
Pharmaceutical Institute Tohoku University
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宮崎 浩
日本化薬(株)経営企画室
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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福田 英臣
Faculty Of Pharmaceutical Sciences Nagoya City University
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福田 英臣
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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舘江 栃郎
Research Laboratories Of Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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塩沢 明
日本化薬
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塩沢 明
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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蔵重 修二
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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成田 和久
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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伊藤 真治
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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宮崎 浩
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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竹井 征夫
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku CO., Ltd.,
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竹井 征夫
Research Laboratories Of Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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成田 和久
日本化薬
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坂本 尚夫
東北大院薬
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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坂本 尚夫
東北大学大学院薬学研究科
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伊藤 真治
Research Laboratories Of Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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蔵重 修二
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku CO., Ltd.,
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