Studies on Pyrimidine Derivatives. XV. Homolytic Acylation and Amidation of Simply Substituted Pyrimidines
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概要
- 論文の詳細を見る
The reaction of 2,6-disubstituted pyrimidines with acyl radicals generated either from pyruvic acid-AgNO_3-(NH_4)_2S_2O_8 (method A) or from aldehyde-FeSO_4-t-BuOOH (method B) in aq. H_2SO_4,gave the corresponding 2,6-disubstituted 4-acylpyrimidines. However, 4,6-disubstituted pyrimidines gave 2-acetyl-and 2,5-diacetyl-4,6-disubstituted pyrimidines under the same conditions (methods A and B). Similarly, homolytic amidation of pyrimidines in which the 2- or 4-positions are free yielded pyrimidine-2- or -4-carboxamides.
- 公益社団法人日本薬学会の論文
- 1980-01-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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逆井 武次
Pharmaceutical Institute, Tohoku University
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小野 隆康
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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小野 隆康
Pharmaceutical Institute Tohoku University
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逆井 武次
Pharmaceutical Institute Tohoku University
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