Synthesis of 5-(Substituted Alkyl) picolinic Acids. The Dopamine β-Hydroxylase Inhibitors. II

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概要

• 論文の詳細を見る

• The improved synthesis of 5-(4-chlorobutyl) picolinic acid (II), the potent dopamine β-hydroxylase inhibitor, was reported. The key intermediate, 2-cyclopropyl-5-cyclopropylcarbonylpyridine (IV) was converted to 5-(4-chlorobutyl)-2-cyclopropylpyridine (VII), which was directly oxidized with nitric acid to give II. Similarly, fusaric acid (I) was synthesized from 2-cyclopropyl-5-(cyclopropylhydroxy) methylpyridine (V).

• 公益社団法人日本薬学会の論文
• 1978-08-25

著者

• 逆井 武次

  Pharmaceutical Institute, Tohoku University

• 濱野 弘明

  Research Laboratory, Pharmaceutical Division, Nippon Kayaku Co., Ltd.

• 濱野 弘明

  Research Laboratory Pharmaceutical Division Nippon Kayaku Co. Ltd.

• 宮野 耕一

  Research Laboratory, Pharmaceutical Division, Nippon Kayaku Co., Ltd.

• 逆井 武次

  Research Laboratory, Pharmaceutical Division, Nippon Kayaku Co., Ltd.

• 逆井 武次

  Pharmaceutical Institute Tohoku University

• 宮野 耕一

  Research Laboratory Pharmaceutical Division Nippon Kayaku Co. Ltd.

関連論文

• Studies on Pyrimidine Derivatives. XXXIII. Synthesis of Alkyl Pyrimidinyl Ketones by Means of Nitrosation of Alkylpyrimidines
• Studies on Dimethoxyphenylaminoalcohols. III. The Enantiomers of 1-(2,5-Dimethoxyphenyl)-3-diethylamino-n-butanol
• Studies on Dimethoxyphenylaminoalcohols. II. Syntheses and Relative Configulations of 1-Dimethoxyphenyl-3-(alkylamino) butanols
• Studies on Pyrimidine Derivatives. XV. Homolytic Acylation and Amidation of Simply Substituted Pyrimidines
• Synthesis of 5-(Substituted Alkyl) picolinic Acids. The Dopamine β-Hydroxylase Inhibitors. II
• Synthesis of 5-(Substituted Alkyl) Picolinic Acids, the Dopamine β-Hydroxylase Inhibitors. I
• Studies on Pyrimidine Derivatives. XXII. Site-selective Oxidation of Dimethylpyrimidines with Selenium Dioxide to Pyrimidine-minoaldehydes
• Studies on Pyrimidine Derivatives. XVI. Site Selectivity in the Homolytic Substitution of Simple Pyrimidines

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