Novel Synthesis of a Dihydroxyethylene Isostere of Renin Inhibitors
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概要
- 論文の詳細を見る
A dihydroxyethylene isostere, (2S, 3R, 4S)-4-amino-5-cyclohexyl-1-morpholino-2,3-pentanediol (ACMP, 1), which is a component of non-peptidic, orally active, low-molecular-weight renin inhibitors, was synthesized stereospecifically starting from 3-cyclohexyl-L-alanine via iodo-cyclocarbamation as the key reaction.
- 公益社団法人日本薬学会の論文
- 1994-10-15
著者
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厚海 修吾
Structural Biology & Chemistry, New Drug Discovery Research Laboratories, Tsukuba Research Institute
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森島 甫
Structural Biology & Chemistry, New Drug Discovery Research Laboratories, Tsukuba Research Institute
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森島 甫
Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu
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池浦 千夏
Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu
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本間 光貴
Structural Biology & Chemistry, New Drug Discovery Research Laboratories, Tsukuba Research Institute
-
厚海 修吾
Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu
-
本間 光貴
Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu
関連論文
- Synthesis of C-Nucleosides by Ring Transformation of 1,3-Oxazine Derivatives
- Synthesis of Imidazo[1,5-a]pyrimidines
- Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpyrimidin-4 (3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)
- Renin Inhibitors. III. Synthesis and Structure-Activity Relationships of Transition-State Inhibitors Containing Dihydroxyethylene Isostere at the P_1-P_ Site
- Renin Inhibitors. II. Synthesis and Structure-Activity Relationships of N-Terminus Modified Inhibitors Containing a Homostatine Analogue
- Renin Inhibitors. I. Synthesis and Structure-Activity Relationships of Transition-State Inhibitors Containing Homostatine Analogues at the Scissile Bond
- A New Approach to the Stereospecific Synthesis of a Dihydroxyehylene Isostere
- Novel Synthesis of a Dihydroxyethylene Isostere of Renin Inhibitors