Glycosides Having Chromophores as Substrates for Sensitive Enzyme Analysis. II. Synthesis of Phenolindophenyl-β-D-glucopyranosides Having an Electron-Withdrawing Substituent as Substrates for β-Glucosidase

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概要

• 論文の詳細を見る

• Five glucopyranosides, resorufinyl- (1), resazurinyl- (2), N-oxyphenolindophenyl- (3), phenolindo-3'-fluorophenyl- (4), and phenolindo-3'-azaphenyl-β-D-glucopyranoside (5), were synthesized through two routes. Compounds 1,2,and 3 were synthesized by direct glycosidation of phenolindophenols. Compounds 4 and 5 were synthesized via the condensation of 4-aminophenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosides (11 and 15) with p-quinone. These glucopyranosides (1-4) were hydrolyzed by β-glucosidase to give blue products showing high abseobance (ε : 22000-39000). They are considered to be potential substrates for the assay of β-glucosidase.

• 公益社団法人日本薬学会の論文
• 1990-12-25

著者

• 加藤 元彦

  Research And Development Division Kikkoman Corporation

• 葛西 浩一

  Research And Development Division Kikkoman Corporation

• 山次 信幸

  Research and Development Division, Kikkoman Corporation

• 徳武 昌一

  Research and Development Division, Kikkoman Corporation

• 冨倉 正

  Research and Development Division, Kikkoman Corporation

• 山次 信幸

  Research And Development Division Kikkoman Corporation

• 徳武 昌一

  キッコーマン 研究本部

• 冨倉 正

  Research And Development Division Kikkoman Corporation

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