Synthesis of 1,2- and 2,3-Dimethoxy-4-methylestratrienes

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概要

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• The synthesis of 1,2-and 2,3-dimethoxy-4-methylestra-1,3,5(10)-trien-17β-ols (XIIIc, VIIIc) from androsta-1,4-diene-3,17-dione (I), which is readily available as the microbial transformation product derived from cholesterol, has been undertaken. The desired compounds could be obtained by introducing an oxygen function into 1-and 3-methoxy-4-methylestratrienes (XIc, VId) employing Friedel-Crafts reaction with acetyl chloride followed by Baeyer-Villiger oxidation as shown in Chart 1 and 2.

• 公益社団法人日本薬学会の論文
• 1972-02-25

著者

• 加藤 元彦

  Research And Development Division Kikkoman Corporation

• 島田 和武

  東北大学薬学部

• 藤井 洋一

  Pharmaceutical Institute, Tohoku University

• 藤井 洋一

  Pharmaceutical Institute Tohoku University

• 加藤 元彦

  Central Research Laboratories of Kikkoman Shoyu Co., Ltd.

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

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