Synthesis of 16-Substituted 14,17-cis-5α-Cardenolides

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概要

• 論文の詳細を見る

• The attempts were made to synthesize 16-substituted 14,17-cis-5α-cardenolides by the method worked out by Ruzicka, et al. starting from 16β-methyl-14α, 17α- and 16α-cyano-14β, 17β-pregnan-20-one derivatives (I and VI). Condensation with ethyl bromoacetate followed by dehydration gave the unsaturated acid esters, which on selenium dioxide oxidation were led to the desired cardenolides (IV and IX). However, Reformatsky reaction with 3β-acetoxy-16α-methyl-14β, 17β-pregn-5-en-20-one (V) resulted in failure probably due to the steric interaction with the methyl group at C-16.

• 公益社団法人日本薬学会の論文
• 1971-01-25

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 合屋 周次郎

  Pharmaceutical Institute, Medical Faculty, University of Kyushu

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 後藤 順一

  Pharmaceutical Institute Tohoku University

• 合屋 周次郎

  Pharmaceutical Institute Tohoku University

• 合屋 周次郎

  Pharmaceutical Institute Medical Faculty University Of Kyushu

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

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