Syntheses of 13α-Progestagens
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概要
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In order to examine the structure-activity relationship the syntheses of some progestagens with the abnormal 13α-configuration have been undertaken. Epimeric 17-ethynyl-17-hydroxy derivatives (II and VII) having Δ^4-3-ketone system were prepared from the corresponding Δ^5-3β-ols (I and VI) by Oppenauer oxidation, respectively. 17-Acetoxy-13α-pregn-4-ene-3,20-diones (V and Xb) were prepared by Jones oxidation from 3β, 17-dihydroxy-13α-pregn-5-en-20-one 17-acetates (IIIc and VIIIc) which were readily available from the 3,17-diacetates (IIIb and VIIIb) by partial hydrolysis. The occurrence of D-homo-annulation of 17-hydroxy-13α-pregnen-20-ones (IIIa and VIIIa) with aluminum isopropoxide has also been described.
- 社団法人日本薬学会の論文
- 1973-03-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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後藤 順一
Pharmaceutical Institute Tohoku University
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須藤 賢一
Pharmaceutical Institute Tohoku University
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佐々木 章子
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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佐々木 章子
Pharmaceutical Institute Tohoku University
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