Mechanism for Interference of Carbamazepine in Porter-Silber Reaction for Determination of Urinary 17-Hydroxycorticosteroids
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概要
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The mechanism by which dosage of carbamazepine (5H-dibenz [b, f] azepine-5-carboxamide) interferes with the Porter-Silber reaction for the determination of urinary 17-hydroxycorticosteroids has been investigated. A specimen of human urine collected following oral administration of carbamazepine was processed in the usual manner. The principal metabolites responsible for the Porter-Silber test were separated and characterized to be carbamazepine-10,11-epoxide and dihydrocarbamazepine-10,11-trans-diol by usual criteria. Being treated with the incomplete Porter-Silber reagent, these metabolites underwent facile rearrangement yielding acridine-9-aldehyde accompanied with a small amount of acridine. It has been disclosed that the interference in the determination of 17-hydroxycorticosteroids due to the undesirable coloration is ascribable to the formation of acridine-9-aldehyde phenylhydrazone from the drug metabolites.
- 社団法人日本薬学会の論文
- 1976-12-25
著者
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小川 善資
北里大学医療衛生学部臨床化学研究室
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南原 利夫
Pharmaceutical Institute, Tohoku University
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小川 善資
北里大学医療衛生学部
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島田 和武
東北大学薬学部
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島田 和武
Pharmaceutical Institute, Tohoku University
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林 長蔵
The Central Laboratory for Clinical Investigation, Osaka University Hospital
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林 長蔵
The Central Laboratory For Clinical Investigation Osaka University Hospital
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南原 利夫
Pharmaceutical Institute Tohoku University
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島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
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