Use of New Silylating Agents for Identification of Hydroxylated Steroids by Gas Chromatography-Electron Impact-Mass Spectrometry
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概要
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A difference of methylene unit value, Δ [MU], was used for the determination of hydroxyl group number of steroid by means of gas chromatography. This index is defined by the difference in the methylene unit value between trimethylsilyl and other dimethylalkylsilyl (DMAS) ether derivatives, namely dimethylethylsilyl (DMES) and dimethyl-n-propylsilyl (DMPS) ethers, of hydroxy-steroid. Mass spectra of these derivatives were characterized by the molecular ion cluster, M, M-15 and M-29 (or M-43), where the fragment ion of M-29 (or M-43) appeared in the most case as a base peak. The molecular ion cluster of these derivatives is of great use for estimating the molecular weight. There-fore, these DMAS ethers provide a valuable information for structural elucidation of hydroxy-steroids by gas chromatography-electron impact-mass spectrometry.
- 公益社団法人日本薬学会の論文
- 1975-11-25
著者
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石橋 正兀
Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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石橋 正兀
日本化薬(株)医薬事業本部総合研究所
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南原 利夫
Pharmaceutical Institute, Tohoku University
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宮崎 浩
寿製薬研究部
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宮崎 浩
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku Co., Ltd.,
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石橋 正兀
Research Laboratories Of Pharmaceuticals Group Nippon Kayaku Co. Ltd.
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伊藤 正大
Research Laboratories, Pharmaceutical Group, Nippon Kayaku Co.,
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伊藤 正大
日本化薬株式会社医薬事業本部学術部
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南原 利夫
Pharmaceutical Institute Tohoku University
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伊藤 正大
日本化薬
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伊藤 正大
Research Laboratories Pharmaceutical Group Nippon Kayaku Co.
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