Studies on Metabolism of 3-Deoxysteroids. VII. Migration of Deuterium during Aryl Hydroxylation of 3-Deoxyestrone
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概要
- 論文の詳細を見る
In order to examine the occurrence of "NIH shift"during hydroxylation of the aromatic steroid, 2-and 3-deuterio-3-deoxyestrones (IIIb, V) were synthesized as substrate. After oral administration of these labeled steroids to a rabbit, two principal metabolites, 2-hydroxy-3-deoxyestrone (Ib) and 17α-estradiol, were isolated from the collected urine specimen. Inspection of mass and nuclear magnetic resonance spectra revealed that aryl hydroxylation was accompanied by a migration of deuterium from the initially labeled site to an adjacent position. The direction and extent of isotope migration are listed in Table I.
- 社団法人日本薬学会の論文
- 1971-01-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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沼澤 光輝
Pharmaceutical Institute Tohoku University
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秋山 節子
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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