Isolation and Characterization of Cardiac Steroids from Seeds of Elaeopendron glaucum PERS. Structures of Elaeodendrosides A, D, E, H, I, J and Elaeodendrogenin

スポンサーリンク

概要

• 論文の詳細を見る

• Six cardiac glycosides having a methylenedioxy group in the sugar moiety, elaeodendroside A, D, E, H, I and J, were isolated from seeds of Elaeodendron glaucum PERS. Their structures were elucidated on the basis of chemical correlation with elaeodendroside A, which was characterized by X-ray analysis. A new cradiac steroid named elaeodendrogenin was also isolated from the same plant materials and its structure was established by direct comparison with a synthetic sample obtained from digitoxigenin. The cardiac activities of these compounds were tested with Straub's preparation.

• 社団法人日本薬学会の論文
• 1982-11-25

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 興野 智子

  Pharmaceutical Institute, Tohoku University

• 内田 逸郎

  Department of Chemistry, University of Virginia

• 島田 和武

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 内田 逸郎

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,

• 南原 利夫

  東北大学医学部薬学科

• 興野 智子

  Pharmaceutical Institute Tohoku University

• 内田 逸郎

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

関連論文

• Studies on Steroid Conjugates. VIII. Synthesis of 16β-Hydroxyestrone 16-Glucuronide Acetate-Methyl Ester
• Occurrence of Bufogenin Conjugates in the Skin of Korean Toad(Organic,Chemical)
• Occurrence of Marinobufotoxin and Telocinobufotoxin Homologs in the Skin of Bufo bankorensis BORBOUR(Organic,Chemical)
• Occurrence of Bufadienolides in the Skin of Bufo viridis LAUR.
• Syntheses of 4-Hydroxyesteriol Monoglucuronides and Monosulfates
• Isolation and Characterization of Cinobufagin 3-Glutaroyl-L-arginine Ester from Bufo bufo gargarizans CANTOR
• Studies on High-Performance Liquid Chromatography with Electrochemical Detection. The pH-Dependency of Enzymic Sulfation of Catechol Estrogens
• Preparation of Specific Antisera to Digoxin Using Hapten-[C-17]-and [C-12]-Bovine Serum Albumin Conjugates
• Syntheses of 4-Hydroxyestrogen Monoglucuronides and Monosulfates
• Isolation and Characterization of Cardiac Steroids from Seeds of Elaeopendron glaucum PERS. Structures of Elaeodendrosides A, D, E, H, I, J and Elaeodendrogenin
• Isolation and Characterization of a New Type of Bufotoxin from the Skin of Bufo americanus
• Isolation and Characterization of Cardiotonic Steroids from the Bulb of Urginea altissima BAKER
• New Derivatization of Amines for Electrochemical Detection in Liquid Chromatography
• Isolation and Characterization of Cardiotonic Steroid Conjugates from the Skin of Bufo marinus (L.) SCHNEIDER
• New Derivatization for Liquid Chromatographic Resolution of Amino Acid Enantiomers
• Studies on Cardiotonic Steroids from the Skin of Japanese Toad
• Mechanism for Interference of Carbamazepine in Porter-Silber Reaction for Determination of Urinary 17-Hydroxycorticosteroids
• Separation and Determination of Cardiac Steroids by High-Pressure Liquid Chromatography
• Isolation and Characterization of Human Urinary Metabolites of Meclomen
• Synthesis of N-(Steroid-17-yl)-maleimide
• The Mechanism of Lithium Aluminum Hydride Reduction of 13α-Steroidal 16,17-Bromohydrins
• An Enzyme Immunoassay System with a Monoclonal Antibody for the Determination of 11-Deoxycortisol(Analytical,Chemical)
• Production and Specificity of a Monoclonal Anti-11-deoxycortisol Antibody
• Bridging Phenomena in Steroid Immunoassays. The Effect of Bridge Length on Sensitivity in Enzyme Immunoassay
• THE BRIDGE LENGTH EFFECT ON SENSITIVITY IN STEROID ENZYME IMMUNOASSAY
• AN ENZYME IMMUNOASSAY METHOD WITH A MONOCLONAL ANTIBODY FOR THE DETERMINATION OF 11-DEOXYCORTISOL
• Enzyme Immunoassay for Plasma 11-Deoxycortisol. Application to Metyrapone Test
• PRODUCTION OF A MONOCLONAL ANTI-11-DEOXYCORTISOL ANTIBODY
• The Specificity of Enzyme Immunoassays for Plasma 11-Deoxycortisol
• Radioimmunoassay of 11-Deoxycortisol. Specificity of Antisera raised against 11-Deoxycortisol-[C-4]-Bovine Serum Albumin Conjugates
• The Specificity in Enzyme Immunoassay for Plasma and Urine Cortisol
• Specificity of Antisera raised against Cortisol-4-Bovine Serum Albumin Conjugates in Radioimmunoassay
• Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl) benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry
• Preparation of New Haptens for Use in Immunoassay of Glycine-Conjugated Bile Acids
• Sensitivity and Specificity in Enzyme Immunoassay of Testosterone
• Synthesis of Corticosteroid Haptens Possessing the Bridge at the C-4 Position
• The Preparation of Steroid N-Hydroxysuccinimide Esters and Their Reactivities with Bovine Serum Albumin
• New Synthesis of 16β-Hydroxydehydroepiandrosterone and Related Ketols, with Special Reference to Preparation of Haptens
• Chemical Synthesis of 11-Deoxycortisol Metabolites
• Glucuronidation of Testosterone by Rat Liver Microsomes
• Production of optically Specific Antiserum to l-Pentazocine
• Specificity of Antiserum raised against Estetrol using 6-O-Carboxymethyloxime-Bovine Serum Albumin Conjugate
• Specificity of Antisera raised against Estradiol using New Hapten-Carrier Conjugates
• Syntheses of New Haptens for Radioimmunoassay of Estradiol
• Occurrence of Cysteine Conjugate of 2-Hydroxyestrone in Rat Bile, with Special Reference to Its Formation Mechanism
• Studies on Metabolism of 3-Deoxysteroids. X. Increased Activity of 3-Deoxyestrone Hydroxylases in Liver Microsomes of Rats pretreated with Phenobarbital and 3-Methylcholanthrene
• Studies on Metabolism of 3-Deoxysteroids. VIII. Isolation and Characterization of Conjugated Metabolites of 3-Deoxyestrone
• Estrogen-Glutathione Conjugate : Metabolite of 3-Deoxyestrone in Rat
• Studies on Metabolism of 3-Deoxysteroids. VII. Migration of Deuterium during Aryl Hydroxylation of 3-Deoxyestrone
• Occurrence of "NIH Shift"during Hydroxylation of Aromatic Steroid
• Studies on Metabolism of 3-Desoxyestrone. II. Isolation and Characterization of Urinary Metabolites of 3-Desoxyestrone in Rabbit
• Further Studies on Metabolites of 3-Desoxyestrone in Rabbit Urine
• Studies on Metabolism of 3-Desoxyestrone. I. Synthesis of 16,17-Oxygenated Estra-1,3,5 (10)-trienes
• Metabolites of 3-Desoxyestrone in Rabbit Urine
• Syntheses of C_ 13α-Steroidal Progestagens
• Syntheses of 13α-Progestagens
• Epimerization of C-17 Substituent during Formation of Isobufadienolide
• Studies on the Comparative Ability of β-Glucuronidase Preparations to Hydrolyze Bile Acid Glucuronides
• Synthesis and Biochemical Aromatization of 14β-and 13α-Androst-4-en-3-ones
• REDUCTIVE BIOTRANSFORMATION OF 3-OXO BILE ACIDS IN HUMAN BLOOD
• Studies on Estetrol. I. Synthesis of 15α, 16α, 17β-Trihydroxy-androst-4-en-3-one
• Synthesis of Epimeric 2-Deuterioestr-4-ene-3,17-diones
• Use of New Silylating Agents for Identification of Hydroxylated Steroids by Gas Chromatography-Electron Impact-Mass Spectrometry
• Analytical Chemical Studies on Steroids. XX. Zimmermann Reaction and Deuterium Exchange Reactivity of Oxosteroids and Related Compounds
• The Bromination of 13α-Androstan-15-one
• Studies on Steroid Conjugates. XII. Occurrence of 16-Epiestriol 16-Glucuronide in Human Pregnancy Urine
• Studies on Steroid Conjugates. XI. Biosynthesis of 16-Epiestriol Glucosiduronate
• Studies on Steroid Conjugates. V. Synthesis of 16-Epiestriol 3-Glucuronide
• Acyl Transfer during Borohydride Reduction of Steroidal 16,17-Ketol Acetates
• Studies on Steroid Conjugates. II. Synthesis of 16-Epiestriol Monoglucuronides
• Chemistry of 3-Phenylcholestan-3-ols
• Enzyme Labeling of Steroids by the Activated Ester Method
• Syntheses of Estriol Monoglucuronides.
• A Direct Enzyme Immunoassay of 6β-Hydroxycortisol in Human Urine
• Studies on Steroid Conjugates. XIV. Participation of Glucuronidation in Selective O-Methylation of Catechol Estrogen in the Rat
• Evidence for O-Methylation of Catechol Estrogen 2-Glucuronoside with Retention of Conjugate in the Rat
• Isolation and Characterization of Biliary Metabolites of Estrone in the Rat
• Isomeric 2,16α-Dihydroxyestrone Methyl Ethers : New Metabolites in Rat Bile
• Studies on Steroid Conjugates. X. Significance of Conjugation involved in Biosynthesis of 2-Methoxyestrogen
• 2-Methoxyestrone 3-Glucuronide : A New Biliary Metabolite in the Rat
• C-2 Hydroxylation of 2-Deuterioestrogen in the Rat. Lack of "NIH Shift"
• Studies on Steroid Conjugates. IV. Synthesis of Catechol Estrogen Monoglucuronides
• Studies on Steroid Conjugates. III. New Syntheses of 2-Methoxyestrogens
• The Synthesis and Zimmermann Reaction of Some Androsten-16-ones
• Studies on Metabolism of 3-Desoxyestrone. III. Synthesis of 6-Oxygenated Estra-1,3,5 (10)-trienes and Related Compounds
• 7-Oxodihydrokarounidiol [7-Oxo-D : C-friedo-olean-8-ene-3α, 29-diol], a Novel Triterpene from Trichosanthes kirilowii
• Triterpenoid Ketones from Lingnania chungii MOCLURE : Arborinone, Friedelin and Glutinone
• Chemical Conversion of Corticosteriods to 3α, 5α-Tetrahydro Derivatives. Synthesis of 5α-Cortol 3-Glucuronides and 5α-Cortolone 3-Glucuronides
• Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetra-hydrocortisol Glucuronides and Allotetrahydrocortisone Glucuronides
• Sensitivity of Steroid Enzyme Immunoassays. Comparison of Four Label Enzymes in an Assay System Using a Monoclonal Anti-steroid Antibody
• UNEXPECTED LOSS OF IMMUNOREACTIVITY OF A GLUCOSE OXIDASE-LABELED ANTIGEN IN A STEROID ENZYME IMMUNOASSAY SYSTEM
• Bound/Free Separation Methods in Steroid Enzyme Immunoassay with Monoclonal Antibody
• Sensitivity of Steroid Enzyme Immunoassays. : Use of 3,3', 5,5'-Tetramethylbenzidine as a Chromogen in the Assay System with Glucose Oxidase Label
• Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Glucose Oxidase-Labeled Antigen for Use in Enzyme Immunoassay(Analytical,Chemical)
• A Comparison of Chromogenic Substrates for Horseradish Peroxidase as a Label in Steroid Enzyme Immunoassay
• Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Alkaline Phosphatase-Labeled Antigen for Use in Enzyme Immunoassay
• Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetrahydro-11-deoxycortisol Glucuronides
• Syntheses of 16,17-Dihydroxy-17-methyl-5α-androstano [3,2-c] isoxazoles
• Analytical Chemical Studies on Steroids. LXIII. Steroid Numbers of Androstanones and Their Oxime Derivatives on Gas Chromatography
• Reactions of 5α, 14β-Pregn-16-en-20-one with Nucleophiles

もっと見る 閉じる

スポンサーリンク