Occurrence of Cysteine Conjugate of 2-Hydroxyestrone in Rat Bile, with Special Reference to Its Formation Mechanism
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概要
- 論文の詳細を見る
The biliary excretion of the water-soluble metabolites in the rat administered with 2-hydroxyestrone-6,7-^3H and estrone-4-^<14>C has been investigated. A polar metabolite separated from the collected bile was characterized to be a conjugate of 2-hydroxyestrone with cysteine at C-1 or C-4 through a sulfide linkage. The in vitro experiment with the rat liver preparation also demonstrated the formation of the cysteine conjugate. Based upon the ^3H/^<14>C values of 2-hydroxyestrone and its cysteine conjugate the probable mechanism involved in conjugation has been discussed.
- 社団法人日本薬学会の論文
- 1974-03-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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田中 頼久
三共(株)分析代謝研究所
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沼澤 光輝
Pharmaceutical Institute Tohoku University
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田中 頼久
Pharmaceutical Institute, Tohoku University
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桃野 陽子(堀田)
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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桃野 陽子(堀田)
Pharmaceutical Institute Tohoku University
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