Syntheses of 16,17-Dihydroxy-17-methyl-5α-androstano [3,2-c] isoxazoles

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概要

• 論文の詳細を見る

• In order to clarify the metabolic fate of 17β-hydroxy-17α-methyl-5α-androstano-[3,2-c] isoxazole, preparation of the titled compounds as its potential metabolites has been undertaken. Treatment of the appropriate 5α-androstan-3-ones (I, XIa, and XIb) with ethyl formate provided the 2-hydroxymethylene derivatives (II, XIIa, and XIIb), which in turn were condensed with hydroxylamine to yield the desired isoxazole fused steroids (IV, XIIIa, and XIIIb), respectively.

• 公益社団法人日本薬学会の論文
• 1973-11-25

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 森 美樹子

  Pharmaceutical Institute Tohoku University

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 野久保 宗孝

  Pharmaceutical Institute, Tohoku University

• 岩村 敏

  Pharmaceutical Institute, Tohoku University

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 野久保 宗孝

  First Laboratory Of Clinical Physiology

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