Preparation of Specific Antisera to Digoxin Using Hapten-[C-17]-and [C-12]-Bovine Serum Albumin Conjugates

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概要

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• The preparation and antigenic properties of etianic acid-[C-17]-and digoxin-[C-12]-bovine serum albumin (BSA) conjugates are described. The antisera raised against the conjugate having an [O-[N-(carboxymethyl) carbamoyl] methyl] oxime bridge at C-12 in rabbits were highly specific to digoxin, exhibiting no significant cross-reactions with digoxigenin, or its bis- and monodigitoxosides. The specificity of antisera elicited is discussed in relation to the coupled position of the hapten with BSA.

• 社団法人日本薬学会の論文
• 1984-06-25

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 水澤 重則

  Pharmaceutical Institute, Tohoku University

• 大久保 正

  Pharmaceutical Institute, Tohoku University

• 島田 和武

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 水澤 重則

  Pharmaceutical Institute Tohoku University

• 水沢 重則

  東北大学 薬

• 大久保 正

  Pharmaceutical Institute Tohoku University

• 南原 利夫

  東北大学医学部薬学科

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

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