Synthesis and Biochemical Aromatization of 14β-and 13α-Androst-4-en-3-ones
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概要
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Requirements of the configuration at C-14 and C-13 for the aromatization of C_<19> steroids by human placenta have been investigated. For this puropose 14β-and 13α-androst-4-en-3-ones were synthesized as the substrate (see Chart 2). The C/D-cis-linked steroids as well as androsta-4,14-diene-3,17-dione were transformed into the 17-hydroxylated estrogens, when incubated with the placental 10000×g supernatant in the presence of NADPH and oxygen. The relative yield of Kober chromogens produced from these C_<19> steroids was found to be lower than that of androst-4-ene-3,17-dione having normal C/D-ring juncture as listed in Table I.
- 公益社団法人日本薬学会の論文
- 1969-09-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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小林 淑子
Pharmaceutical Institute Tohoku University
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山内 恭子
Pharmaceutical Institute, Tohoku University
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山内 恭子
Pharmaceutical Institute Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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