REDUCTIVE BIOTRANSFORMATION OF 3-OXO BILE ACIDS IN HUMAN BLOOD
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概要
- 論文の詳細を見る
7α, 12α-Dihydroxy-3-oxo-5β-cholanoic acid labeled with ^<18>O atoms was incubated with human blood, and the biotransformation products were separated and characterized by gas chromatography-mass spectrometry as the pentafluorobenzyl ester-trimethylsilyl and -dimethylethylsilyl ether derivatives. 3β, 7α, 12α-Trihydroxy-5β-cholanoic acid was identified as a main metabolite. When 3-oxo bile acid was incubated with human blood denatured at 70℃ for 2 min, no metabolites were formed. The enzymic reduction activity proved to be localized in the red blood cell fraction.
- 公益社団法人日本薬学会の論文
- 1989-07-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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後藤 順一
Pharmaceutical Institute Tohoku University
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安藤 昌幸
Product Research and Development Laboratories, Pharmaceuticals Research Center, Kanebo Ltd.
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牧野 勲
Second Department Of Internal Medicine Asahikawa Medical College
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南原 利夫
東北大学医学部薬学科
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安藤 昌幸
Product Research And Development Laboratories Pharmaceuticals Research Center Kanebo Ltd.
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三浦 裕也
Pharmaceutical Institute, Tohoku University
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安藤 昌幸
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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三浦 裕也
Pharmaceutical Institute Tohoku University
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