Studies on Steroid Conjugates. X. Significance of Conjugation involved in Biosynthesis of 2-Methoxyestrogen
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概要
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The role of the conjugate in the biosynthesis of 2-methoxyestrogen in the living animal has been explored by the double-isotope technique. The isotope ratios of the isomeric catechol estrogen monomethyl ethers excreted in urine after simultaneous administration of estrone-4-^<14>C and estrone-6,7-^3H sulfate or estradiol-6,7-^3H 3-glucuronide were determined. Comparison of the ^3H/^<14>C value with that of the administered steroid implies that the sulfate conjugation may possibly participate in the predominant formation of 2-methoxyestrogen, while the conjugation with glucuronic acid may not. The dimethyl ether of catechol estrogen was metabolized with random O-demethylation yielding two isomeric monomethyl ethers both in the rat and man. Therefore it appears that the selective O-demethylation may not be involved in the preferential formation of 2-methoxyestrogen.
- 公益社団法人日本薬学会の論文
- 1972-10-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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本間 誠次郎
Pharmaceutical Institute Tohoku University
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金山 紀世子
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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金山 紀世子
Pharmaceutical Institute Tohoku University
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