Synthesis of Corticosteroid Haptens Possessing the Bridge at the C-4 Position
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概要
- 論文の詳細を見る
In order to obtain specific antisera for use in radioimmunoassay and enzyme immunoassay, new haptens of cortisol, 11-deoxycortisol and cortisone were prepared. The synthesis of the 4-hemisuccinates of 4-hydroxycortisol and 4-hydroxy-11-deoxycortisol was accomplished by employing suitably protected 21-mono-tert-butyldimethylsilyl ethers of the 4-hydroxysteroids as key intermediates. As another type of hapten, the 4-carboxy-methylthio derivatives of corticosteroids were prepared by base-catalyzed ring opening of the 4,5-epoxide with mercaptoacetic acid. In addition, the preparation of related haptens is described.
- 社団法人日本薬学会の論文
- 1980-04-25
著者
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宮入 伸一
Pharmaceutical Institute Tohoku University
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宮入 伸一
東北大学薬学部
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南原 利夫
Pharmaceutical Institute, Tohoku University
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細田 宏
Pharmaceutical Institute Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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