Syntheses of 4-Hydroxyesteriol Monoglucuronides and Monosulfates

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概要

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• The A-ring monoglucuronides and monosulfates of 4-hydroxyesteriol were synthesized from 4-hydroxyestriol 16,17-diacetate by means of the Koenigs-Knorr reaction with methyl α-acetobromoglucuronate and sulfation with sulfur trioxide-pyridine complex, respectively. The conjugated positions of these compounds were unequivocally elucidated by leading the products to guaiacol estrogens. The D-ring monoglucuronides and monosulfates of 4-hydroxyestriol were also obtained from 4-hydroxyestriol 3,4-dibenzyl ether by glucuronidation and sulfation followed by hydrogenolysis, respectively. The conjugated positions were established on the basis of spectral data of derivatives. The preparation of 4-hydroxyestradiol 17-conjugates is also described.

• 社団法人日本薬学会の論文
• 1986-01-25

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 謝 福明

  Pharmaceutical Institute, Tohoku University

• 島田 和武

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 南原 利夫

  東北大学医学部薬学科

• 謝 福明

  Pharmaceutical Institute Tohoku University

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

関連論文

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