Studies on Metabolism of 3-Deoxysteroids. X. Increased Activity of 3-Deoxyestrone Hydroxylases in Liver Microsomes of Rats pretreated with Phenobarbital and 3-Methylcholanthrene
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概要
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Effects of the pretreatment with phenobarbital or 3-methylcholanthrene on the hydroxylase activity of rats liver microsomes were examined with 3-deoxyestrone. The administration of phenobarbital stimulated the 6β-hydroxylase, while the 3-methyl-cholanthrene treatment increased the rate of aromatic hydroxylation selectively. The biotransformation products formed from 3-deoxyestrone with the hepatic microsomes could be characterized by the reverse isotope dilution method and the chromatographic behaviors.
- 社団法人日本薬学会の論文
- 1972-06-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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沼澤 光輝
Pharmaceutical Institute Tohoku University
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石岡 静子
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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石岡 静子
Pharmaceutical Institute Tohoku University
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