New Synthesis of 16β-Hydroxydehydroepiandrosterone and Related Ketols, with Special Reference to Preparation of Haptens

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概要

• 論文の詳細を見る

• A new method for the preparation of 16β-hydroxy-17-keto steroids has been developed. 16β-Hydroxylated dehydroepiandrosterone, epiandrosterone, androsterone and estrone were prepared from the corresponding 3,16-diacetate through the 17-ethylenehemithioketal. 16β-Hydroxydehydroepiandrosterone 3-hemisuccinate for the use of immunoassay as a hapten was prepared from the 3β, 16β-dihydroxy-17-ketone ethylenehemithioketal by the sequential reactions : tert-butyldimethylsilylation of the hydroxyl functions, selective desilylation followed by hemisuccinylation at C-3,and removal of protecting groups at C-16 and C-17. The synthesis of the related 16,17-ketol derivatives has also been described.

• 社団法人日本薬学会の論文
• 1978-07-25

著者

• 宮入 伸一

  Pharmaceutical Institute Tohoku University

• 宮入 伸一

  東北大学薬学部

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 奥山 智子

  Pharmaceutical Institute Tohoku University

• 細田 宏

  Pharmaceutical Institute Tohoku University

• 佐藤 淑子

  Pharmaceutical Institute, Tohoku University

• 神谷 香恵子

  Pharmaceutical Institute, Tohoku University

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 神谷 香恵子

  Pharmaceutical Institute Tohoku University

• 佐藤 淑子

  Pharmaceutical Institute Tohoku University

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