Synthesis of 15-Oxo- and Δ^<16>-14β-Isobufadienolides
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概要
- 論文の詳細を見る
In order to clarify the structure-activity relationship, synthesis of the titled compounds has been undertaken. The acid-cleavage of 14α, 15α-epoxyisobufadienolide (I) followed by oxidation with chromium trioxide gave the 14β-hydroxy-15-ketone (III). The ring opening of the β-epoxide (IV) and subsequent epimerization at C-14 resulted in formation of 15-oxo-14β-isobufadienolide (VI). Upon treatment with N-bromosuccinimide and then with lithium chloride or sodium iodide 14β, 17α- and 14α, 17β-isobufadienolides (IX and XIII) were led to Δ^<16>, Δ^<14,16> and Δ^<16>-14β, 15β-epoxy derivatives (X, XV and XVI), respectively.
- 公益社団法人日本薬学会の論文
- 1971-01-25
著者
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島田 和武
東北大学薬学部
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島田 和武
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
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