Synthesis of 16-Methyl-14,17-cis-5-dehydro- and -5α-Isobufadienolides
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概要
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In order to examine the cardiotonic and anti-tumor activities, synthesis of 16-methyl-14,17-cis-5-dehydro- and 5α-isobufadienolides, in which C-17 is linked to 6-position of the 2-pyrone ring, has been undertaken. These cardiotonic steroid analogs have been prepared through the general route, namely condensation with ethyl orthoformate and then with malonic acid followed by cyclization to 2-pyrone, starting from the 16-methylpregnan-20-ones, which possess the desired configuration at C-14 and C-17. The synthesis of the corresponding 14α, 17β-isobufadienolides is also described.
- 公益社団法人日本薬学会の論文
- 1968-11-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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合屋 周次郎
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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島田 和武
Pharmaceutical Institute, Tohoku University
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後藤 順一
Pharmaceutical Institute Tohoku University
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合屋 周次郎
Pharmaceutical Institute Tohoku University
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合屋 周次郎
Pharmaceutical Institute Medical Faculty University Of Kyushu
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南原 利夫
Pharmaceutical Institute Tohoku University
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