Isolation and Characterization of New Bufotoxins from the Skin of Bufo melanostictus SCHNEIDER
スポンサーリンク
概要
- 論文の詳細を見る
The occurrence of new bufotoxins, in which L-histidine, L-3-methylhistidine, or L-1-methylhistidine replaces the arginine residue of hitherto known "bufotoxin, " in the skin of the Formosan toad, Bufo melanostictus SCHNEIDER, is reported. Five novel bufotoxins, bufotalin 3-suberoyl-L-histidine, -3-methylhistidine and -1-methylhistidine esters and 19-hydroxybufalin 3-suberoyl-L-histidine and -3-methylhistidine esters, were separated by usual chromatographic methods including reversed phase high-performance liquid chromatography, and their structures were elucidated by degradative and synthetic means.
- 社団法人日本薬学会の論文
- 1984-11-25
著者
-
島田 和武
東北大学薬学部
-
島田 和武
Pharmaceutical Institute, Tohoku University
-
大石 和夫
Pharmaceutical Institute, Tohoku University
-
島田 和武
Faculty of Pharmaceutical Sciences, Kanazawa University
-
大石 和夫
Central Research Laboratories, Ajinomoto Co., Inc.,
-
南原 利夫
東北大学医学部薬学科
-
大石 和夫
Central Research Laboratories Ajinomoto Co. Inc.
-
島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
関連論文
- 18.C-ノル-D-ホモステロイドアルカロイドの合成 : ステロイド母核の構造について
- ヒキガエルとストレス (ストレスを科学する--メカニズムと最近の話題)
- Occurrence of Bufogenin Conjugates in the Skin of Korean Toad(Organic,Chemical)
- Occurrence of Marinobufotoxin and Telocinobufotoxin Homologs in the Skin of Bufo bankorensis BORBOUR(Organic,Chemical)
- Occurrence of Bufadienolides in the Skin of Bufo viridis LAUR.
- Syntheses of 4-Hydroxyesteriol Monoglucuronides and Monosulfates
- Isolation and Characterization of Cinobufagin 3-Glutaroyl-L-arginine Ester from Bufo bufo gargarizans CANTOR
- Studies on High-Performance Liquid Chromatography with Electrochemical Detection. The pH-Dependency of Enzymic Sulfation of Catechol Estrogens
- Isolation and Characterization of New Bufotoxins from the Skin of Bufo melanostictus SCHNEIDER
- Preparation of Specific Antisera to Digoxin Using Hapten-[C-17]-and [C-12]-Bovine Serum Albumin Conjugates
- A Direct Radioimmunoassay of Estradiol 3-Glucuronide Using Specific Antiserum
- Syntheses of 4-Hydroxyestrogen Monoglucuronides and Monosulfates
- Isolation and Characterization of Cardiac Steroids from Seeds of Elaeopendron glaucum PERS. Structures of Elaeodendrosides A, D, E, H, I, J and Elaeodendrogenin
- Isolation and Characterization of a New Type of Bufotoxin from the Skin of Bufo americanus
- Isolation and Characterization of Cardiotonic Steroids from the Bulb of Urginea altissima BAKER
- New Derivatization of Amines for Electrochemical Detection in Liquid Chromatography
- Isolation and Characterization of Cardiotonic Steroid Conjugates from the Skin of Bufo marinus (L.) SCHNEIDER
- New Derivatization for Liquid Chromatographic Resolution of Amino Acid Enantiomers
- Studies on Cardiotonic Steroids from the Skin of Japanese Toad
- Mechanism for Interference of Carbamazepine in Porter-Silber Reaction for Determination of Urinary 17-Hydroxycorticosteroids
- Separation and Determination of Cardiac Steroids by High-Pressure Liquid Chromatography
- Syntheses and Enzymatic Hydrolysis of 25-Hydroxyvitamin D Monoglucuronides
- Radioimmunoassay Method for the Determination of 22-Oxacalcitriol, a Novel Analog of 1α, 25-Dihydroxyvitamin D_3 Having Valuable Clinical Potency, in Rat and Human Plasma
- PRODUCTION OF HIGHLY SPECIFIC ANTIBODIES TO 1α, 25-DIHYDROXYVITAMIN D_3 UTILIZING A NOVEL HAPTENIC DERIVATIVE HAVING A CHEMICAL BRIDGE AT 11α-POSITION
- Production and Specificity of Anti-22-oxacalcitriol Antisera
- NOVEL DERIVATIZATION REAGENT WITH TETRATHIAFULVALENE AS AN ELECTROPHORE FOR PRE-COLUMN LABELING OF AMINES IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
- 蛍光検出高速液体クロマトグラフィーによる体液中Isofloxythepin の測定
- Isolation and Characterization of Human Urinary Metabolites of Meclomen
- 電気化学検出高速液体クロマトグラフィ-による牛肉中の残留Zeranol及びEstradiolの分析法について
- ECD-ガスクロマトグラフィ-による脱リン酸Bromophenophosの分析法とウシ乳汁中排泄について
- 高速液体クロマトグラフィ-による食品中のテオブロミン,テオフィリン及びカフェインの同時分析法
- An Enzyme Immunoassay System with a Monoclonal Antibody for the Determination of 11-Deoxycortisol(Analytical,Chemical)
- Production and Specificity of a Monoclonal Anti-11-deoxycortisol Antibody
- Bridging Phenomena in Steroid Immunoassays. The Effect of Bridge Length on Sensitivity in Enzyme Immunoassay
- THE BRIDGE LENGTH EFFECT ON SENSITIVITY IN STEROID ENZYME IMMUNOASSAY
- AN ENZYME IMMUNOASSAY METHOD WITH A MONOCLONAL ANTIBODY FOR THE DETERMINATION OF 11-DEOXYCORTISOL
- Enzyme Immunoassay for Plasma 11-Deoxycortisol. Application to Metyrapone Test
- PRODUCTION OF A MONOCLONAL ANTI-11-DEOXYCORTISOL ANTIBODY
- The Specificity of Enzyme Immunoassays for Plasma 11-Deoxycortisol
- Effect of Bridge Heterologous Combination on Sensitivity in Enzyme Immunoassay for 11-Deoxycortisol
- Radioimmunoassay of 11-Deoxycortisol. Specificity of Antisera raised against 11-Deoxycortisol-[C-4]-Bovine Serum Albumin Conjugates
- The Specificity in Enzyme Immunoassay for Plasma and Urine Cortisol
- Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl) benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry
- 微量有機成分の定量法--生物学的親和性を利用する分析法--総論
- Preparation of New Haptens for Use in Immunoassay of Glycine-Conjugated Bile Acids
- Chemical Synthesis of 11-Deoxycortisol Metabolites
- N-Alkylated 1,4-Dihydropyridines : New Agents to Overcome Multidrug Resistance
- ステロイドの分析化学的研究(第45報)Androst-4-ene-3,6,17-trioneのポーラログラフ的挙動
- ステロイドの分析化学的研究(第39報) : ケトステロイドメチルオキシム誘導体のポーラログラフィー
- ステロイドの分析化学的研究(第38報) : 不飽和ケトステロイドのポーラログラフィー
- 21世紀薬学に向って
- Epimerization of C-17 Substituent during Formation of Isobufadienolide
- Studies on the Comparative Ability of β-Glucuronidase Preparations to Hydrolyze Bile Acid Glucuronides
- REDUCTIVE BIOTRANSFORMATION OF 3-OXO BILE ACIDS IN HUMAN BLOOD
- Stereospecific Dehydrogenation of (25R)-and (25S)-3α, 7α, 12α-Trihydroxy-5β-cholestanoic Acids by Acyl-CoA Oxidase in Rat Liver Light Mitochondrial Fraction
- ガスクロマトグラフ/質量分析法による体液中のイフェンプロジルの定量(医薬品の分析)
- 21世紀薬学像を探る
- A Direct Enzyme Immunoassay of 6β-Hydroxycortisol in Human Urine
- "地方"の研究者にも光を(活気ある支部活動)
- Synthesis of 1,2- and 2,3-Dimethoxy-4-methylestratrienes
- Chemical Conversion of Corticosteriods to 3α, 5α-Tetrahydro Derivatives. Synthesis of 5α-Cortol 3-Glucuronides and 5α-Cortolone 3-Glucuronides
- Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetra-hydrocortisol Glucuronides and Allotetrahydrocortisone Glucuronides
- Sensitivity of Steroid Enzyme Immunoassays. Comparison of Four Label Enzymes in an Assay System Using a Monoclonal Anti-steroid Antibody
- UNEXPECTED LOSS OF IMMUNOREACTIVITY OF A GLUCOSE OXIDASE-LABELED ANTIGEN IN A STEROID ENZYME IMMUNOASSAY SYSTEM
- Bound/Free Separation Methods in Steroid Enzyme Immunoassay with Monoclonal Antibody
- Sensitivity of Steroid Enzyme Immunoassays. : Use of 3,3', 5,5'-Tetramethylbenzidine as a Chromogen in the Assay System with Glucose Oxidase Label
- Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Glucose Oxidase-Labeled Antigen for Use in Enzyme Immunoassay(Analytical,Chemical)
- 17α-ヒドロキシプロゲステロンの蛍光酵素イムノアッセイ法
- A Comparison of Chromogenic Substrates for Horseradish Peroxidase as a Label in Steroid Enzyme Immunoassay
- Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Alkaline Phosphatase-Labeled Antigen for Use in Enzyme Immunoassay
- Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetrahydro-11-deoxycortisol Glucuronides
- Syntheses of 16,17-Dihydroxy-17-methyl-5α-androstano [3,2-c] isoxazoles
- Potential Bile Acid Metabolites. XXI. A New Synthesis of Allochenodeoxycholic and Allocholic Acids
- Potential Bile Acid Metabolites. XV. : Synthesis of 4β-Hydroxylated Bile Acids; Unique Bile Acids in Human Fetal Bile
- A Gas Chromatographic-Mass Spectrometric Method for the Evaluation of Bioconversion of Indomethacin Prodrugs into the Parent Drug
- Occurrence of Bufalitoxin, Cinobufotoxin and Their Homologs in Japanese Toad
- Synthesis of Monosulfates of Cholic Acid Derivatives
- ステロイド類のバイオメディカル分析(学術研究の動向)
- 合成ステロイド剤 (広範囲血液・尿・化学検査--その数値をどう読むか) -- (薬物検査)
- 放射性医薬品の最近の話題-7-ラジオイムノアッセイの最近の進歩ステロイドを中心として
- Analysis of Conjugated Bile Acids in Human Biological Fluids. Synthesis of Hyodeoxycholic Acid 3- and 6-Glycosides and Related Compounds
- 強心性ステロイドアナログの研究(第5報) : 17β(orα)-Isoxazolyl and Pyrazolyl-16-methyl-14β(or α)-androst-5-enesの合成
- NEW TYPE OF DERIVATIZATION REAGENTS FOR LIQUID CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERIC HYDROXYL COMPOUNDS
- A New Sensitive Derivatization Reagent for Liquid Chromatographic Separation of Hydroxyl Compounds
- Synthesis of 16-Substituted 14,17-cis-5α-Cardenolides
- Synthesis of 14,15-Epoxyandrostan-17β-yl-isoxazoles and -pyrazoles
- Synthesis of 14,15-Epoxyisobufadienolides
- Synthesis of 16-Methyl-14,17-cis-5-dehydro- and -5α-Isobufadienolides
- Reactions of 14β, 15β-Epoxypregn-16-en-20-one with Nucleophiles
- 28 日本産ガマ外皮の強心成分について
- New Synthesis of Phenolphthalein β-Glucuronide
- Mechanism for Interference of Ethinamate in Zimmermann Test for Determination of Urinary 17-Ketosteroids
- Syntheses of D-Homo-14β-pregnan-20-ones
- Occurrence of Novel Type Bufotoxin in Japanese Toad
- Syntheses of Bufotoxin Analogs
- Syntheses of Digitoxigenin 3-Suberoy1peptides
- Synthesis of 3-Suberoylamino Acid Esters of Digitoxigenin
- Synthesis of 3-Suberoylalanine Ester of Digitoxigenin
- Synthesis of 15-Oxo- and Δ^-14β-Isobufadienolides
- Radioimmunoassay for Estradiol 3-Sulfate 17-Glucuronide in Serum Using Specific Antiserum without Deconjugation 1)