ステロイドの分析化学的研究(第45報)Androst-4-ene-3,6,17-trioneのポーラログラフ的挙動
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Polarographic behaviors of androst-4-ene-3,6,17-trione (I) in aqueous dimethylformamide and acetonitrile containing 0.1 M LiCl as a supporting electrolyte were examined. In 50% acetonitrile solution, I showed one reduction wave corresponding to two electrons at -0.75_5 V vs. S.C.E., whereas in 50% dimethylformamide solution, two reduction waves appeared, involving two electrons in all at -0.81_0 and -1.48_5 V vs. S.C.E. In the case of aqueous dimethylformamide, the total limiting current was constant and the height ratio of the 1st wave to the 2nd was dependent on dimethylformamide concentration. The controlled potential electrolysis of I in aqueous dimethylformamide resulted in the formation of 5α-androstane-3,6,17-trione (IX). These results together with the ultraviolet spectral data revealed that in dimethylformamide solution, I exists in the keto-enol equilibrated state, and the 1st and 2nd waves are ascribable to the reduction of keto and 6-enol forms, respectively.
- 社団法人日本薬学会の論文
- 1971-06-25
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