Studies on Analysis of Bile Acids. Preparation of 3-Glucuronides of 7- and 12-Oxo Bile Acids
スポンサーリンク
概要
- 論文の詳細を見る
The 3-glucuronides of unconjugated and glyco- and tauro-conjugated bile acids having a 7- or 12-oxo group have been synthesized. Introduction of a glucuronyl residue at the C-3 position was achieved by the Koenigs-Knorr reaction using cadmium carbonate as a catalyst. The 3-glucuronides of conjugated bile acids were prepared by three sequential reactions : esterification with p-nitrophenol, glucuronidation at C-3,and amide formation with ethyl glycinate or taurine. The nuclear magnetic resonance spectral properties of 3-glucuronides of oxo bile acids and related compounds are briefly discussed.
- 公益社団法人日本薬学会の論文
- 1982-12-25
著者
-
後藤 順一
Pharmaceutical Institute Tohoku University
-
南原 利夫
東北大学医学部薬学科
-
砂崎 和彦
Pharmaceutical Institute, Tohoku University
-
南原 利夫
Pharmaceutical Institute Tohoku University
-
砂崎 和彦
Pharmaceutical Institute Tohoku University
関連論文
- ヒキガエルとストレス (ストレスを科学する--メカニズムと最近の話題)
- Occurrence of Bufogenin Conjugates in the Skin of Korean Toad(Organic,Chemical)
- Occurrence of Marinobufotoxin and Telocinobufotoxin Homologs in the Skin of Bufo bankorensis BORBOUR(Organic,Chemical)
- Occurrence of Bufadienolides in the Skin of Bufo viridis LAUR.
- Syntheses of 4-Hydroxyesteriol Monoglucuronides and Monosulfates
- Isolation and Characterization of Cinobufagin 3-Glutaroyl-L-arginine Ester from Bufo bufo gargarizans CANTOR
- Studies on High-Performance Liquid Chromatography with Electrochemical Detection. The pH-Dependency of Enzymic Sulfation of Catechol Estrogens
- Isolation and Characterization of New Bufotoxins from the Skin of Bufo melanostictus SCHNEIDER
- Preparation of Specific Antisera to Digoxin Using Hapten-[C-17]-and [C-12]-Bovine Serum Albumin Conjugates
- A Direct Radioimmunoassay of Estradiol 3-Glucuronide Using Specific Antiserum
- Syntheses of 4-Hydroxyestrogen Monoglucuronides and Monosulfates
- Isolation and Characterization of Cardiac Steroids from Seeds of Elaeopendron glaucum PERS. Structures of Elaeodendrosides A, D, E, H, I, J and Elaeodendrogenin
- New Derivatization for Liquid Chromatographic Resolution of Amino Acid Enantiomers
- 蛍光検出高速液体クロマトグラフィーによる体液中Isofloxythepin の測定
- Isolation and Characterization of Human Urinary Metabolites of Meclomen
- 電気化学検出高速液体クロマトグラフィ-による牛肉中の残留Zeranol及びEstradiolの分析法について
- ECD-ガスクロマトグラフィ-による脱リン酸Bromophenophosの分析法とウシ乳汁中排泄について
- 高速液体クロマトグラフィ-による食品中のテオブロミン,テオフィリン及びカフェインの同時分析法
- An Enzyme Immunoassay System with a Monoclonal Antibody for the Determination of 11-Deoxycortisol(Analytical,Chemical)
- Production and Specificity of a Monoclonal Anti-11-deoxycortisol Antibody
- Bridging Phenomena in Steroid Immunoassays. The Effect of Bridge Length on Sensitivity in Enzyme Immunoassay
- THE BRIDGE LENGTH EFFECT ON SENSITIVITY IN STEROID ENZYME IMMUNOASSAY
- AN ENZYME IMMUNOASSAY METHOD WITH A MONOCLONAL ANTIBODY FOR THE DETERMINATION OF 11-DEOXYCORTISOL
- Enzyme Immunoassay for Plasma 11-Deoxycortisol. Application to Metyrapone Test
- PRODUCTION OF A MONOCLONAL ANTI-11-DEOXYCORTISOL ANTIBODY
- The Specificity of Enzyme Immunoassays for Plasma 11-Deoxycortisol
- Effect of Bridge Heterologous Combination on Sensitivity in Enzyme Immunoassay for 11-Deoxycortisol
- Radioimmunoassay of 11-Deoxycortisol. Specificity of Antisera raised against 11-Deoxycortisol-[C-4]-Bovine Serum Albumin Conjugates
- The Specificity in Enzyme Immunoassay for Plasma and Urine Cortisol
- Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl) benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry
- 微量有機成分の定量法--生物学的親和性を利用する分析法--総論
- Preparation of New Haptens for Use in Immunoassay of Glycine-Conjugated Bile Acids
- Chemical Synthesis of 11-Deoxycortisol Metabolites
- ステロイドの分析化学的研究(第45報)Androst-4-ene-3,6,17-trioneのポーラログラフ的挙動
- ステロイドの分析化学的研究(第39報) : ケトステロイドメチルオキシム誘導体のポーラログラフィー
- ステロイドの分析化学的研究(第38報) : 不飽和ケトステロイドのポーラログラフィー
- 21世紀薬学に向って
- Syntheses of C_ 13α-Steroidal Progestagens
- Syntheses of 13α-Progestagens
- Studies on the Comparative Ability of β-Glucuronidase Preparations to Hydrolyze Bile Acid Glucuronides
- REDUCTIVE BIOTRANSFORMATION OF 3-OXO BILE ACIDS IN HUMAN BLOOD
- Studies on Estetrol. I. Synthesis of 15α, 16α, 17β-Trihydroxy-androst-4-en-3-one
- Stereospecific Dehydrogenation of (25R)-and (25S)-3α, 7α, 12α-Trihydroxy-5β-cholestanoic Acids by Acyl-CoA Oxidase in Rat Liver Light Mitochondrial Fraction
- ガスクロマトグラフ/質量分析法による体液中のイフェンプロジルの定量(医薬品の分析)
- 21世紀薬学像を探る
- A Direct Enzyme Immunoassay of 6β-Hydroxycortisol in Human Urine
- Enzyme Labeling in Steroid Enzyme Immunoassays. The p-Nitrophenyl Ester Method for Alkaline Phosphatase and Glucose Oxidase Labelings
- USE OF THE THERMOSTABLE GLUCOSE-6-PHOSPHATE DEHYDROGENASE AS A LABEL ENZYME IN STEROID ENZYME IMMUNOASSAYS
- Chemical Conversion of Corticosteriods to 3α, 5α-Tetrahydro Derivatives. Synthesis of 5α-Cortol 3-Glucuronides and 5α-Cortolone 3-Glucuronides
- Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetra-hydrocortisol Glucuronides and Allotetrahydrocortisone Glucuronides
- Sensitivity of Steroid Enzyme Immunoassays. Comparison of Four Label Enzymes in an Assay System Using a Monoclonal Anti-steroid Antibody
- UNEXPECTED LOSS OF IMMUNOREACTIVITY OF A GLUCOSE OXIDASE-LABELED ANTIGEN IN A STEROID ENZYME IMMUNOASSAY SYSTEM
- Bound/Free Separation Methods in Steroid Enzyme Immunoassay with Monoclonal Antibody
- Sensitivity of Steroid Enzyme Immunoassays. : Use of 3,3', 5,5'-Tetramethylbenzidine as a Chromogen in the Assay System with Glucose Oxidase Label
- Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Glucose Oxidase-Labeled Antigen for Use in Enzyme Immunoassay(Analytical,Chemical)
- 17α-ヒドロキシプロゲステロンの蛍光酵素イムノアッセイ法
- A Comparison of Chromogenic Substrates for Horseradish Peroxidase as a Label in Steroid Enzyme Immunoassay
- Enzyme Labeling of Steroids by the N-Succinimidyl Ester Method. Preparation of Alkaline Phosphatase-Labeled Antigen for Use in Enzyme Immunoassay
- Chemical Conversion of Corticosteroids to 3α, 5α-Tetrahydro Derivatives. Synthesis of Allotetrahydro-11-deoxycortisol Glucuronides
- Reactions of 5α, 14β-Pregn-16-en-20-one with Nucleophiles
- Potential Bile Acid Metabolites. XXI. A New Synthesis of Allochenodeoxycholic and Allocholic Acids
- Potential Bile Acid Metabolites. XV. : Synthesis of 4β-Hydroxylated Bile Acids; Unique Bile Acids in Human Fetal Bile
- A Gas Chromatographic-Mass Spectrometric Method for the Evaluation of Bioconversion of Indomethacin Prodrugs into the Parent Drug
- Synthesis of Monosulfates of Cholic Acid Derivatives
- Synthesis of Monosulfates of Unconjugated and Conjugated Bile Acids
- Synthesis of Estriol Monoglucoside Derivatives, New Haptens for Production of Specific Antisera
- ステロイド類のバイオメディカル分析(学術研究の動向)
- 合成ステロイド剤 (広範囲血液・尿・化学検査--その数値をどう読むか) -- (薬物検査)
- 放射性医薬品の最近の話題-7-ラジオイムノアッセイの最近の進歩ステロイドを中心として
- Analysis of Conjugated Bile Acids in Human Biological Fluids. Synthesis of Hyodeoxycholic Acid 3- and 6-Glycosides and Related Compounds
- 強心性ステロイドアナログの研究(第5報) : 17β(orα)-Isoxazolyl and Pyrazolyl-16-methyl-14β(or α)-androst-5-enesの合成
- NEW TYPE OF DERIVATIZATION REAGENTS FOR LIQUID CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERIC HYDROXYL COMPOUNDS
- A New Sensitive Derivatization Reagent for Liquid Chromatographic Separation of Hydroxyl Compounds
- Preparation of Haptens for Use in Immunoassays of Tetrahydro-11-deoxycortisol and Its Glucuronides
- Synthesis of Haptens for Use in Immunoassays of Tetrahydrocortisol, Tetrahydrocortisone and Their Glucuronides
- Synthesis of 16-Substituted 14,17-cis-5α-Cardenolides
- ステロイドの分析化学的研究(第22報) : α-ブロム-17-および-16-ケトステロイドのポーラログラフィー
- Synthesis of 16-Methyl-14,17-cis-5-dehydro- and -5α-Isobufadienolides
- Reactions of 14β, 15β-Epoxypregn-16-en-20-one with Nucleophiles
- Synthesis of Cortoic Acid 3-Glucuronides
- Synthesis of Cortol 3-Glucuronides and Cortolone 3-Glucuronides
- New Synthesis of Phenolphthalein β-Glucuronide
- Effect of Bridge Heterologous Combination on Sensitivity in Enzyme Immunoassay for Cortisol
- 南原会頭にきく
- Synthesis of Haptens for Use in Immunoassays of Δ^4-3-Ketosteroids
- 分離分析における誘導体化法の進歩
- 分離分析法の進歩に思う
- 日本薬学会教育賞受賞 鶴藤丞氏の業績
- 光学異性薬物の分離分析
- Synthesis of Disulfates of Unconjugated and Conjugated Bile Acids(Analytical,Chemical)
- 体液中微量胆汁酸の固相抽出(超微量分析のための前処理と予備濃縮)
- 臨床化学分析に用いる呈色反応の機構
- Studies on Analysis of Bile Acids. Preparation of 3-Glucuronides of 7- and 12-Oxo Bile Acids
- Synthesis of Conjugated Cholesterol and Cholestanols
- Studies on Steroid Conjugates. XIII. Synthesis of 2,4,17α-d_3-Estriol 3-Glucuronoside
- Studies on the Metabolism of Atenolol. Characterization and Determination of a New Urinary Metabolite in the Rat
- Syntheses of Epimeric 2- and 4-Deuteriocholesterols
- 薬物の体液中濃度測定法
- 薬学の未来への使命(21世紀へ向けての薬学の創造)
- ソサエティージャーナルとしてのフィロソフィーを(日本薬学会発行の論文誌のあり方をまた考えてみよう)