NEW TYPE OF DERIVATIZATION REAGENTS FOR LIQUID CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERIC HYDROXYL COMPOUNDS
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概要
- 論文の詳細を見る
Two sensitive chiral derivatization reagents, (+)- and (-)-2-methyl-1,1'-binaphthalene-2'-carbonyl nitriles, have been newly developed. These were prepared from dimethyl 1,1'-binaphthalene-2,2'-dicarboxylate in several steps. Enantiomeric alcohols were readily condensed with the chiral reagent in the presence of triethylamine under mild conditions. The diastereomeric esters formed from enantiomeric hydroxy acids were efficiently resolved by high-performance liquid chromatography on a normal phase column with n-pentane/ethyl acetate. These were highly responsive to a fluorescence detector (excitation wavelength 342 nm ; emission wavelength 420 nm) with a detection limit of 200 pg.
- 公益社団法人日本薬学会の論文
- 1982-12-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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後藤 信治
Pharmaceutical Institute Tohoku University
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後藤 順一
Pharmaceutical Institute Tohoku University
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南原 利夫
東北大学医学部薬学科
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南原 利夫
Pharmaceutical Institute Tohoku University
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