ステロイドの分析化学的研究(第22報) : α-ブロム-17-および-16-ケトステロイドのポーラログラフィー

概要

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Polarographic reductions of seven pairs of epimeric a-bromo-17- and -16-ketosteroids were carried out in isopropanol-acetate buffer solution (pH 6.0) (4 : 1) and the relationship between the half-wave potentials and the nature of C-bromine bond was examined on the basis of stereochemical and conformational grounds (Table I). There could be seen the difference in the half-wave potential between each epimer of a-bromoketones ; and the thermodynamically less stable epimer was reduced with more ease than the other one. In addition the reduction of these compounds at the dropping mercury electrode was also influenced by the change of C/D-ring fusion and slgihtly by the structural alteration of ring A and B.
公益社団法人日本薬学会の論文
1969-03-25