Potential Bile Acid Metabolites. XXI. A New Synthesis of Allochenodeoxycholic and Allocholic Acids
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概要
- 論文の詳細を見る
A new method for the preparation of allochenodeoxycholic and allocholic acids is described. The key steps in the synthesis are 1) simultaneous oxidation-dehydrogenation reaction of 3α-hydroxy 5β-bile acid formyl esters with iodoxybenzene catalyzed by benzeneseleninic anhydride, 2) reductive allomerization at C-5 of the 1,4-dien-3-oxo hydroxy acids with lithium/liq. ammonia, and 3) subsequent reduction of the resulting 3-oxo 5α-compounds with K-Selectride.
- 公益社団法人日本薬学会の論文
- 1993-04-15
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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丹羽 俊文
東北大学医学部保健学科
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後藤 順一
Pharmaceutical Institute Tohoku University
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飯田 隆
College Of Engineering Nihon University
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南原 利夫
東北大学医学部薬学科
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南原 利夫
Pharmaceutical Institute Tohoku University
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Chang F
Department Of Chemistry Harvey Mudd College
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西田 信司
College of Engineering, Nihon University
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CHANG Frederic
Department of Chemistry, Harvey Mudd College
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丹羽 俊文
Pharmaceutical Institute, Tohoku University
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CHANG Frederic
Department of Biochemistry, College of Medicine, University of South Alabama
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