ステロイドの分析化学的研究(第39報) : ケトステロイドメチルオキシム誘導体のポーラログラフィー

概要

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Polarographic behavior of the methyloximes of testosterone, pregnenolone, estrone, isoandrosterone, and related ketosteroids was examined. Of these compounds, testosterone methyloxime showed two reduction waves, where the half-wave potentials were linearly dependent on pH. With respect to the reduction process of this compound, a mechanism involving two two-electron reductions has been proposed from the result of controlled potential electrolysis and of pH effect on the rate-determining step (Chart 1). The nonconjugated ketosteroid methyloximes also exhibited a reduction wave in acid solution. The half-wave potential and current constant measured at pH 1.00 are collected in Table IV. In addition, the nature of the polarographic wave characteristic to these compounds has been described.
社団法人日本薬学会の論文
1971-02-25