Studies on the Metabolism of Atenolol. Characterization and Determination of a New Urinary Metabolite in the Rat
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概要
- 論文の詳細を見る
The characterization and quantitation of a new urinary metabolite, M2,from rats orally given atenolol, a β-adrenergic blocking drug, are described. 4-(2-Hydroxy-3-isopropylaminopropoxy) phenylglyoxylic acid amide was synthesized as an authentic sample by an unequivocal route. The structure of M2 was definitively established by direct comparison with the synthetic specimen. Determination of M2 in urine was achieved by means of selected ion monitoring (SIM) using [^3H_6]-atenolol as an internal standard. The amount of M2 excreted in urine was estimated to be 1.04% of the dose.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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松木 容彦
社団法人日本食品衛生協会食品衛生研究所
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松木 容彦
Hatano Research Institute, Food and Drug Safety Center
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南原 利夫
東北大学医学部薬学科
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伊東 富晴
財団法人食品薬品安全センター
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伊東 富晴
Hatano Research Institute Food And Drug Safety Center
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南原 利夫
Pharmaceutical Institute Tohoku University
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松木 容彦
国立医薬品食品衛生研究所
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小松 栄
Pharmaceutical Institute, Tohoku University
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小松 栄
Pharmaceutical Institute Tohoku University
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