Analysis of Conjugated Bile Acids in Human Biological Fluids. Synthesis of Hyodeoxycholic Acid 3- and 6-Glycosides and Related Compounds

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概要

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• The glucuronide, glucoside and N-acetylglucosaminide conjugates of hyodeoxycholic acid were synthesized. In addition, murideoxycholic acid 3-glycosides and some of their C-5 epimeric analogs were also prepared. The principal reactions used are 1) the Koenigs-Knorr condensation reaction of 3-oxo-6α-hydroxy and 6-oxo-3α-hydroxy esters with an appropriate α-acetohalosugar catalyzed by cadmium carbonate in benzene under reflux, 2) reduction of the resulting bile acid glycoside methyl ester-acetates with tert-butylamine-borane complex, and 3) subsequent hydrolysis with aqueous lithium hydroxide.

• 公益社団法人日本薬学会の論文
• 1994-07-15

著者

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

• 丹羽 俊文

  東北大学医学部保健学科

• 後藤 順一

  Pharmaceutical Institute Tohoku University

• 飯田 隆

  College Of Engineering Nihon University

• 南原 利夫

  東北大学医学部薬学科

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 丹羽 俊文

  Pharmaceutical Institute, Tohoku University

• 田沢 信之介

  College of Engineering, Nihon University

• 大島 由佳里

  College of Engineering, Nihon University

• 大島 由佳里

  College Of Engineering Nihon University

• 田沢 信之介

  College Of Engineering Nihon University

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