New Synthesis of Phenolphthalein β-Glucuronide

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概要

• 論文の詳細を見る

• Convenient synthesis of phenolphthalein β-glucuronide (IV), which is widely used for the assay of β-glucuronidase activity as a substrate, has been described. Koenigs-Knorr reaction of phenolphthalin methyl ester (I) with methyl acetobromoglucuronate in the presence of cadmium carbonate as a catalyst provided the monoglucuronide acetatemethyl ester (II) which on oxidation with 2,3-dichloro-5,6-dicyanobenzoquinone was led to the phenolphthalein derivative (III). Elimination of protecting groups with methanolic sodium hydroxide afforded the desired compound (IV) in a satisfactory yield.

• 公益社団法人日本薬学会の論文
• 1976-11-25

著者

• 島田 和武

  東北大学薬学部

• 島田 和武

  Pharmaceutical Institute, Tohoku University

• 後藤 順一

  Pharmaceutical Institute Tohoku University

• 南原 利夫

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 滝澤 徳正

  Pharmaceutical Institute, Tohoku University

• 滝澤 徳正

  Pharmaceutical Institute Tohoku University

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