28 日本産ガマ外皮の強心成分について

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概要

• 論文の詳細を見る

• Three new types of bufotoxins in which the succinoyl, adipoyl, and pimeloyl groups are displaced for the suberoyl residue of the so-called "bufotoxin" have been separated from the skin of Japanese toad Bufo vulgaris formosus Boulenger. In addition, four bufogenin 3-sulfates and two novel conjugated cardenolides named cardenobufotoxin have also been isolated. The ethanolic extract of the skin obtained from 1,800 toads was separated by chromatography on Amberlite XAD-2 resin, silica gel, and Sephadex LH-20 and, if necessary, by high-speed liquid chromatography to provide new cardiotonic steroid conjugates. The structures of these substances were elucidated to be resibufogenin 3-succinoylarginine ester (Id), bufalin 3-succinoylarginine ester (IIb), gamabufotalitoxin homologs (IIId, IIIh, IIIk, IIIm), bufogenin 3-sulfates (IV, V, VI, VII), and cardenobufotoxins (VIIId, VIIIf) by degradative and synthetic means.

• 天然有機化合物討論会の論文
• 1975-10-01

著者

• 島田 和武

  東北大学薬学部

• 藤井 洋一

  Pharmaceutical Institute, Tohoku University

• 新崎 百合子

  Pharmaceutical Institute, Tohoku University

• 藤井 洋一

  Pharmaceutical Institute Tohoku University

• 南原 利夫

  東北大・薬学部

• 三石 悦子

  東北大・薬

• 新崎 百合子

  Pharmaceutical Institute Tohoku University

• 島田 和武

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 島田 和武

  東北大・薬

• 藤井 洋一

  東北大・薬

• 新崎 百合子

  東北大・薬

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