NOVEL DERIVATIZATION REAGENT WITH TETRATHIAFULVALENE AS AN ELECTROPHORE FOR PRE-COLUMN LABELING OF AMINES IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
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概要
- 論文の詳細を見る
A novel derivatization reagent with tetrathiafulvalene as an electrophore, N-succinimidyl tetrathiafulvalene-2-carboxylate, was prepared and evaluated for pre-column labeling of amine by using β-phenethylamine as a model compound in high-performance liquid chromatography with electrochemical detection. The reagent reacted readily with the primary amine at room temperature for 1 h, providing the amide which was highly responsive to an electrochemical detector (detection limit = 21 fmol, signal to noise ratio = 5) at a relatively low applied potential (+700 mV vs. Ag/AgCl). The characteristic two-stage oxidative pattern appeared on the hydrodynamic voltammogram of the derivative, which helped to identify the peak on the chromatogram.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
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島田 和武
金沢大学大学院自然科学研究科
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島田 和武
東北大学薬学部
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島田 和武
Faculty of Pharmaceutical Sciences, Kanazawa University
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大江 知行
Faculty of Pharmaceutical Sciences, Kanazawa University
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大江 知行
Faculty Of Pharmaceutical Sciences Kanazawa University
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大江 知行
Pharmaceutical Institute Tohoku University
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島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
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