Syntheses and Enzymatic Hydrolysis of 25-Hydroxyvitamin D Monoglucuronides
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概要
- 論文の詳細を見る
25-Hydroxyvitamin D_3 (D_2) 3- and 25-monoglucuronides were synthesized from the corresponding provitamin D or its derivatives with the Koenigs-Knorr reaction using silver carbonate as a catalyst, followed by photochemical reaction, thermal isomerization and then alkali hydrolysis. The obtained glucuronides were subjected to enzymatic hydrolysis using β-glucuronidase, and substrate specificities were found in the examined enzymes originating from different sources.
- 社団法人日本薬学会の論文
- 1995-08-15
著者
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島田 和武
金沢大学大学院自然科学研究科
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三田村 邦子
金沢大学薬学部
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島田 和武
Faculty of Pharmaceutical Sciences, Kanazawa University
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菅谷 克子
Faculty of Pharmaceutical Sciences, Kanazawa University
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鍛冶 秀文
Faculty of Pharmaceutical Sciences, Kanazawa University
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中谷 糸
Faculty of Pharmaceutical Sciences, Kanazawa University
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三田村 邦子
Faculty of Pharmaceutical Sciences, Kanazawa University
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[ツツミ] 紀子
Faculty of Pharmaceutical Sciences, Kanazawa University
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中谷 糸
Faculty Of Pharmaceutical Sciences Kanazawa University
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菅谷 克子
Faculty Of Pharmaceutical Sciences Kanazawa University
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鍛冶 秀文
Faculty Of Pharmaceutical Sciences Kanazawa University
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島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
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Shimada Kazutake
Fcaulty Of Pharmaceutical Sciences Kanazawa University
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