Syntheses of Digitoxigenin 3-Suberoy1peptides
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概要
- 論文の詳細を見る
In order to obtain the more potent cardiotonic drug digitoxigenin 3-suberoylpeptides whose peptide moieties are derived from the partial structure of kinin, have been synthesized. Some of the desired compounds were prepared from digitoxigenin 3-suberoyl-p-nitrophenol (I) by direct condensation with the pertinent di- or tri-peptide. As for the steroidal peptides having the readily unavailable amino acid sequence the stepwise method involving the repeated p-nitrophenyl ester formation was carried out. The condensation reaction of p-nitrophenyl ester with amino acid or peptide was considerably improved in respect with the yield, when the amino group was activated by leading to the carbamate.
- 公益社団法人日本薬学会の論文
- 1973-05-25
著者
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島田 和武
東北大学薬学部
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島田 和武
Pharmaceutical Institute, Tohoku University
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藤井 洋一
Pharmaceutical Institute, Tohoku University
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藤井 洋一
Pharmaceutical Institute Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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島田 和武
Faculty Of Pharmaceutical Sciences Kanazawa University
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