Studies on the Synthesis of Compounds Related to Adenosine 3', 5'-Cyclic Phosphate. V. : Synthesis and Cardiac Effect of N^6-Alkyladenosine 3', 5'-Cyclic Phosphates and Their 8-Benzylthio Derivatives

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概要

• 論文の詳細を見る

• A series of N^6-alkyladenosine 3', 5'-cyclic phosphates (N^6-alkyl cAMPs) (3) and N^6-alkyl-8-benzylthio cAMPs (4) was synthesized from cAMP (1) and 8-benzylthio cAMP (2) by means of a one-pot reaction. This reaction proceeded by reductive alkylation in acetic acid with aldehydes and sodium cyanoborohydride. These cAMP derivatives were evaluated for inotropic and chronotropic effects on the isolated guinea pig papillary muscle and right atria. Several N^6-alkyl cAMPs (3) were surprisingly more active than compounds 4 in these actions. Among them, N^6-hexyl cAMP (3f) and M^6-heptyl cAMP (3g) showed strongly positive inotropic effects (PIE) and moderately negative chronotropic effects.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 加藤 元彦

  Research And Development Division Kikkoman Corporation

• 河田 登美枝

  Department Of Pharmacology School Of Medicine Niigata University

• 片岡 茂博

  Research and Development Division, Kikkoman Corporation

• 山次 信幸

  Research and Development Division, Kikkoman Corporation

• 今井 昭一

  Department of Pharmacology, School of Medicine, Niigata University

• 磯野 純子

  Research and Development Division, Kikkoman Corporation

• 片岡 茂博

  キッコーマン

• 今井 昭一

  Department Of Pharmacology School Of Medicine Niigata University

• 山次 信幸

  Research And Development Division Kikkoman Corporation

• 磯野 純子

  Research And Development Division Kikkoman Corporation

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