Studies on the Syntheses of Compounds related to Adenosine 3', 5'-cyclic Phosphate. II. Removal of Etheno Group of 2-Substituted 1,N^6-Etheno-adenosine 3', 5'-cyclic Phosphates
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概要
- 論文の詳細を見る
Treatment of 2-substituted 1,N^6-etheno-c-AMP (c-AMP : adenosine 3', 5'-cyclic phosphate) derivatives with N-bromosuccinimide (NBS) under mild conditions gave the corresponding 2-substituted-c-AMP. Therefore, the route (c-AMP→1,N^6-etheno-c-AMP→2-substituted 1,N^6-etheno-c-AMP→2-substituted c-AMP) offers an excellent way to synthesize the last compound from c-AMP. The yields of this deblocking reaction of the etheno group were increased by the adjustment of the solution to alkaline after bromination. The probable reaction mechanism involving the bromination and the subsequent hydrolysis has been proposed.
- 公益社団法人日本薬学会の論文
- 1977-12-25
著者
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加藤 元彦
Research And Development Division Kikkoman Corporation
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山次 信幸
Research and Development Division, Kikkoman Corporation
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加藤 元彦
Central Research Laboratories of Kikkoman Shoyu Co., Ltd.
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山次 信幸
Central Research Laboratories of Kikkoman Shoyu Co., Ltd.
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尾上 泰子
Research Laboratory of Seishin Pharmaceutical Co., Ltd.
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山次 信幸
Research And Development Division Kikkoman Corporation
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尾上 泰子
Research Laboratory Of Seishin Pharmaceutical Co. Ltd.
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