The Synthesis of 2-Substituted 1,N^6-Etheno-adenosine-3', 5'-cyclic Phosphate by Ring Reclosure of Alkali-hydrolizate of 1,N^6-Etheno-adenosine-3', 5'-cyclic Phosphate
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概要
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An useful procedure for the synthesis of 2-substituted 1,N^6-etheno-adenosine-3', 5'-cyclic phosphates by ring closure of 3-β-D-(3', 5'-cyclic phospho)-ribofuranosyl-4-amino-5-(imidazol-2-yl)-imidazole (II), under relative mild conditions, is reported. Treatment of the compound II with bromine cyanide, triethyl orthoacetate, 1,1'-carbonyldiimidazole and carbon disulfide gave 2-amino-, 2-methyl-, 2-hydroxy-, and 2-mercapto-1,N^6-etheno-adenosine-3', 5'-cyclic phosphate (c-AMP), respectively. Moreover, several 2-alkylmercapto-, 2-benzylmercapto-, and 2-bromo-1,N^6-etheno-c-AMP were synthesized from 2-merc apto-1,N^6-etheno-c-AMP. 2-Methoxy-, 2-azido-, 2-dimethylamino-1,N^6-etheno-c-AMP were synthesized from 2-bromo-1,N^6-etheno-c-AMP. The fluorescent and ultraviolet spectra of 2-substituted 1,N^6-etheno-c-AMP are tabulated.
- 公益社団法人日本薬学会の論文
- 1976-07-25
著者
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加藤 元彦
Research And Development Division Kikkoman Corporation
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山次 信幸
Research and Development Division, Kikkoman Corporation
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加藤 元彦
Central Research Laboratories of Kikkoman Shoyu Co., Ltd.
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山次 信幸
Central Research Laboratories of Kikkoman Shoyu Co., Ltd.
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湯浅 泰子
Research Laboratory of Seishin Pharmaceutical Co., Ltd.
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湯浅 泰子
Research Laboratory Of Seishin Pharmaceutical Co. Ltd.
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山次 信幸
Research And Development Division Kikkoman Corporation
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