Inotropic and Chronotropic Actions of 2-Substituted and 8-Substituted Derivatives of Adenosine 3', 5'-Cyclic Monophosphate

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概要

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• We synthesized several 2- and 8-substituted derivatives of adenosine 3', 5'-cyclic monophosphate (c-AMP), and examined the effects of these compounds on the isolated atrial muscle preparation of the guinea pig. We found that several 8-substituted c-AMPs could produce definite positive inotropic and chronotropic effects, even when applied from outside the cell, while all the 2-substituted c-AMPs produced negative inotropic and chronotropic effects. Pretreatment of the preparation with aminophylline resulted in a potentiation of the positive inotropic and chronotropic effects of 8-substituted c-AMPs, while the negative inotropic and chronotropic effects of 2-substituted c-AMPs were abolished. The mechanisms by which these effects were produced are discussed.

• 公益社団法人日本薬学会の論文
• 1980-06-25

著者

• 加藤 元彦

  Research And Development Division Kikkoman Corporation

• 山次 信幸

  Research and Development Division, Kikkoman Corporation

• 今井 昭一

  Department of Pharmacology, School of Medicine, Niigata University

• 加藤 元彦

  Central Research Laboratories of Kikkoman Shoyu Co., Ltd.

• 今井 昭一

  Department Of Pharmacology School Of Medicine Niigata University

• 山次 信幸

  Research And Development Division Kikkoman Corporation

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