CARDIAC ACTION OF DIMORPHOLAMINE
スポンサーリンク
概要
- 論文の詳細を見る
Since the introduction of dimorpholamine (N, N'-dibutyl-N, N'-dicarboxymorpholineethylenediamine, 1064 Th) as a potent analeptic agent, not a few papers have appeared concerning its stimulating action on respiration and blood pressure. However, to the authors' knowledge, only two works have ever been published with respect to its action on the isolated heart. Using the isolated frog's heart, Fukushima (1) observed a positive inotropic action with 0.75 mg/ml of this compound, although the action was very weak and evanescent. According to his study, an isolated preparation of the dog's heart (Starling's heart-lung preparation) responded to this compound in a similar manner, whereas only a slight negative inotropic action could be induced in the isolated perfused rabbit heart. Kanda <I>et al</I>. (2) studied the action of dimorpholamine on the isolated frog heart. They used a higher dosage range of 0.15 to 0.3 mg/ml and found a definite positive inotropic action ; still higher doses produced more marked positive inotropic action, followed after a lapse of time by a disturbance of heart rhythm.<BR> As an exact knowledge of the cardiac action of an analeptic is important in evaluating usefulness of that compound in clinical medicine, the authors felt the necessity to reinvestigate the cardiac action of dimorpholamine in more detail. In the course of the study, a marked positive inotropic action was observed both in the isolated frog's heart (which was essentially the same as reported by Kanda <I>et al</I>.) and in the heart-lung preparation of the dog. Even in the isolated perfused rabbit heart, the authors could produce a positive inotropic action under certain conditions, which the authors at present are not able to specify (see Fig. 6). This report pertains to the detailed description of the action of this potent analeptic agent on the heart-lung preparation of the dog, with special reference to the possible role played by the adrenergic mechanism in the observed positive inotropic action.
著者
-
今井 昭一
Department Of Pharmacology School Of Medicine Niigata University
-
重井 達朗
Department of Pharmacology, Institute for Cardiovascular Diseases and Department of Pharmacology, Fa
-
武田 敬介
Department of Pharmacology, Institute for Cardiovascular Diseases and Department of Pharmacology, Fa
-
村瀬 弘
The 3rd Department of Internal Medicine, Faculty of Medicine, Tokyo Medical & Dental University
-
鹿取 信
Department of Pharmacology, Faculty of Medicine, and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University
-
鹿取 信
Department of Pharmacology, Faculty of Medicine and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
-
武田 敬介
Department of Pharmacology, Faculty of Medicine, and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University
-
重井 達朗
Department of Pharmacology, Faculty of Medicine and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
-
今井 昭一
Department of Pharmacology, Faculty of Medicine, and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University
関連論文
- Studies on the Synthesis of Compounds Related to Adenosine 3', 5'-Cyclic Phosphate. VII. : Synthesis and Cardiac Effects of N^6,N^6-Dialkyl Adenosine 3', 5'-Cyclic Phosphates
- Studies on the Synthesis of Compounds Related to Adenosine-3', 5'-cyclic Phosphate. VI. : Synthesis and Cardiac Effects of N^6,N^6,2'-O-Trialkyl-, N^6,2'-O-Dialkyl-, and 2'-O-Alkyladenosine-3', 5'-cyclic Phosphates
- Studies on the Synthesis of Compounds Related to Adenosine 3', 5'-Cyclic Phosphate. V. : Synthesis and Cardiac Effect of N^6-Alkyladenosine 3', 5'-Cyclic Phosphates and Their 8-Benzylthio Derivatives
- Inotropic and Chronotropic Actions of 2-Substituted and 8-Substituted Derivatives of Adenosine 3', 5'-Cyclic Monophosphate
- THE ACTION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE ON DOG HEART-LUNG PREPARATION
- FAILURE OF KININ FORMATION BY GLASS POWDER IN RAT PLASMA AFTER INJECTION OF BROMELAIN
- PREVENTION OF ADRENALINE-INDUCED PULMONARY EDEMA BY STEM BROMELAIN IN RABBITS AND ANALYSIS OF THE HEMODYNAMIC CHANGES
- PROTECTIVE EFFECT OF STEM BROMELAIN AGAINST ADRENALINE PULMONARY EDEMA, AND ITS DEPENDENCE ON THE PROTEOLYTIC ACTIVITY
- KININASE ACTIVITY OF STEM BROMELAIN
- CARDIAC ACTION OF DIMORPHOLAMINE
- PULMONARY EDEMA INDUCED BY ADRENALINE AND RELATED AMINES IN RATS, AND ITS MODIFICATION BY VARIOUS PRETREATMENTS
- A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS
- PULMONARY EDEMA INDUCED BY EPINEPHRINE INFUSION IN RATS