PROTECTIVE EFFECT OF STEM BROMELAIN AGAINST ADRENALINE PULMONARY EDEMA, AND ITS DEPENDENCE ON THE PROTEOLYTIC ACTIVITY
スポンサーリンク
概要
- 論文の詳細を見る
It was reported previously that pretreatment of rats with a crude preparation of stem bromelain, a thiolprotease obtained from pineapple plant, effectively protected the animals against adrenaline-induced pulmonary edema (1-3). The present study was undertaken to examine whether the edema-preventive effect of the enzyme is due to its proteolytic activity. For this purpose, purified and activated stem bromelain was prepared. A part of this was then inactivated by N-ethylmaleimide, a specific SH-inhibitor. The edema-preventive effects of the two enzyme preparations were compared.
- 社団法人 日本薬理学会の論文
著者
-
重井 達朗
Department of Pharmacology, Institute for Cardiovascular Diseases and Department of Pharmacology, Fa
-
峰下 哲
Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental Universi
-
榎本 つね
Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental Universi
-
峰下 哲
Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University
-
榎本 つね
Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
-
榎本 つね
Department of Pharmacology, Institute for Cardiovascular Diseases Tokyo Medical & Dental University
-
重井 達朗
Department of Pharmacology, Faculty of Medicine and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
関連論文
- THE ACTION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE ON DOG HEART-LUNG PREPARATION
- FAILURE OF KININ FORMATION BY GLASS POWDER IN RAT PLASMA AFTER INJECTION OF BROMELAIN
- PREVENTION OF ADRENALINE-INDUCED PULMONARY EDEMA BY STEM BROMELAIN IN RABBITS AND ANALYSIS OF THE HEMODYNAMIC CHANGES
- PROTECTIVE EFFECT OF STEM BROMELAIN AGAINST ADRENALINE PULMONARY EDEMA, AND ITS DEPENDENCE ON THE PROTEOLYTIC ACTIVITY
- KININASE ACTIVITY OF STEM BROMELAIN
- CARDIAC ACTION OF DIMORPHOLAMINE
- PULMONARY EDEMA INDUCED BY ADRENALINE AND RELATED AMINES IN RATS, AND ITS MODIFICATION BY VARIOUS PRETREATMENTS
- A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS
- PULMONARY EDEMA INDUCED BY EPINEPHRINE INFUSION IN RATS