PREVENTION OF ADRENALINE-INDUCED PULMONARY EDEMA BY STEM BROMELAIN IN RABBITS AND ANALYSIS OF THE HEMODYNAMIC CHANGES

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概要

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• In the course of our researches on the preventive action of stem bromelain (BRM), a protease obtained from pine apple plant, against the adrenaline induced pulmonary edema in rats, it was noticed that a pretreatment with this enzyme also inhibited the occurrence of the circulatory and respiratory changes caused by adrenaline which were remarkable in the nontreated animals (1). This suggested that further analysis of the differences in the hemodynamic pattern might throw light on the mechanism of the pulmonary edema and the mode of action of BRM. In the present study, we made an investigation of the effects of BRM in rabbits and analyzed the data to locate the sites of action from the hemodynamic point of view.

• 社団法人 日本薬理学会の論文

著者

• 重井 達朗

  Department of Pharmacology, Institute for Cardiovascular Diseases and Department of Pharmacology, Fa

• 峰下 哲

  Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental Universi

• 峰下 哲

  Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University

• 峰下 哲

  Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University

• 重井 達朗

  Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University

• 重井 達朗

  Department of Pharmacology, Faculty of Medicine and Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University

関連論文

• THE ACTION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE ON DOG HEART-LUNG PREPARATION
• FAILURE OF KININ FORMATION BY GLASS POWDER IN RAT PLASMA AFTER INJECTION OF BROMELAIN
• PREVENTION OF ADRENALINE-INDUCED PULMONARY EDEMA BY STEM BROMELAIN IN RABBITS AND ANALYSIS OF THE HEMODYNAMIC CHANGES
• PROTECTIVE EFFECT OF STEM BROMELAIN AGAINST ADRENALINE PULMONARY EDEMA, AND ITS DEPENDENCE ON THE PROTEOLYTIC ACTIVITY
• KININASE ACTIVITY OF STEM BROMELAIN
• CARDIAC ACTION OF DIMORPHOLAMINE
• PULMONARY EDEMA INDUCED BY ADRENALINE AND RELATED AMINES IN RATS, AND ITS MODIFICATION BY VARIOUS PRETREATMENTS
• A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS
• PULMONARY EDEMA INDUCED BY EPINEPHRINE INFUSION IN RATS

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