PULMONARY EDEMA INDUCED BY ADRENALINE AND RELATED AMINES IN RATS, AND ITS MODIFICATION BY VARIOUS PRETREATMENTS

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In spite of the vast accumulation of informations over many years, the key mechanism of the adrenaline induced pulmonary edema still remains to be elucidated. We have carried out a series of experiments attempting to obtain further clues for solving the problem. The present paper is concerned with the following subjects: 1) Setting up of a procedure for producing pulmonary edema by continuous infusion of adrenaline solution. This procedure seems to be more appropriate than a single injection for analysis of the sequence of events in the cardiovascular and respiratory systems. 2) Comparison of edema-producing activity of some sympathomimetic amines. This trial may suggest whether the edema production is related to the alpha or beta adrenergic action, or else. 3) Designing of a screening scheme to single out such a pretreatment as would effectively prevent the adrenaline induced pulmonary edema. The effects of some operative procedures, autonomic blocking agents, proteolytic enzymes as well as their inhibitors were examined, and some of them proved to be effective. Parts of the present study were reported previously (1-4).
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