SUPPRESSION OF PHORBOL MYRISTATE ACETATE-INDUCED PLEURISY BY CV-3988,AN ANTAGONIST OF PLATELET-ACTIVATING FACTOR
スポンサーリンク
概要
- 論文の詳細を見る
Pleurisy was induced in rats by intrapleural injection of 10 uM phorbol myristate acetate (PMA) or 2 % carrageenin. Thirty minutes after PMA was administered following pretreatment with CV-3988,a specific antagonist of platelet activating factor (PFA), pleural fluid accumulation and its exudation rate were significantly suppressed. However the pleurisy induced by carrageenin was not affected by CV-3988. These results indicate that PAF may contribute to the exudation of PMA-induced pleurisy but not in carrageenin-induced pleurisy.
- 社団法人日本薬学会の論文
- 1986-11-25
著者
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大石 幸子
昭和大・薬・衛生化学
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林 正彦
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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八巻 幸二
北里大・薬・薬理
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野村 容朗
Central Research Division, Takeda Chemical Ind., Ltd.,
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大石 幸子
北里大学
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野村 容朗
Research and Development Division, Eisai Company, Ltd.,
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大石 幸子
北里大学薬学部薬理学教室
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大石 幸子
北里大学医学部・薬理学
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津島 進
Central research Division, Takeda Chemical Ind., Ltd.
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津島 進
Central Research Division Takeda Chemical Industries Ltd.
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大石 幸子
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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八巻 幸二
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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野村 容朗
Research And Development Division Eisai Company Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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大石 幸子
昭和大 薬
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大石 幸子
Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical & Dental University
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大石 幸子
Department of Pharmacology, Institute for Cardiovascular Diseases Tokyo Medical & Dental University
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